which is the cell structure that is made of dna that gives the master instructions for the cell a..centromere b..chromosome c..allele d..gene

Chromosome is the instruction that consist the gene. A gene is a hereditary unit that is made up of  a sequence of DNA that occupies a specific location or site  on a chromosome, and which can be transcribed or copied into an RNA molecule that may function just as it is, or be translated  into amino acids.